When customer email out and straight away got Retry Timeout Exceeded.

Run the below to reset Exim db:

/usr/sbin/exim_tidydb -t 1d /var/spool/exim retry > /dev/null
/usr/sbin/exim_tidydb -t 1d /var/spool/exim reject > /dev/null
/usr/sbin/exim_tidydb -t 1d /var/spool/exim wait-remote_smtp > /dev/null

and then restart exim.
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